Event

Breast Cancer: Subtypes, Current Therapy, and Patient Prognosis

10 February 2025

What is Cancer Breast ?

Cancer breast is a disease in which cells malignant grow not controlled on the network breasts . Although more often attack women , cancer this is also possible occurs in men (1% of cases ). In Indonesia, Globocan 2020 data take notes 65,858 cases new cancer breasts in women , making it cancer is the most common disease in Indonesia.

Subtype Cancer Breast Cancer : Types, Therapy , and Impact on Prognosis

Cancer breast No disease single . Subtype cancer breast determined by expression receptor cell cancer , which affects therapy and prognosis. Here are 4 subtypes main :

1. Luminal A

· Receptors : ER+, PR+, HER2-

· Characteristics : Growth slow , best prognosis

· Therapy : Therapy hormones (Tamoxifen, Aromatase Inhibitors)

2. Luminal B

· Receptors : ER+, PR+/-, HER2+/-

· Characteristics : More aggressive from Luminal A

· Therapy : Combination therapy hormones + chemotherapy ± HER2 targeted therapy

3. HER2-Enriched

· Receptors : ER-, PR-, HER2+

· Characteristics : Aggressive , but response Good with targeted therapy

· Therapy : Trastuzumab (Herceptin®), Pertuzumab

4. Triple-Negative Breast Cancer (TNBC)

· Receptors : ER-, PR-, HER2-

· Characteristics : Most aggressive , risk relapse tall

· Therapy : Chemotherapy ± immunotherapy ( Example : Pembrolizumab)

Cancer Prognosis Breast Based on Subtype

Subtype	5 Year Survival Rate	Risk Recurrence
Luminal A	90-95%	Low
Luminal B	80-85%	Currently
HER2-Enriched	75-80%*	Tall**
TNBC	60-70%	Very high

Mammaprint : Test Genetics For Personalization Therapy

Mammaprint is test genetics revolutionary that analyzes 70 genes to predict risk relapse . The main benefits :

1. Determine need chemotherapy addition

2. Avoid overtreatment of patients risk low

3. Guiding decision therapy more accurate

Prevention Cancer Breast with a SMART Lifestyle Pattern

Indonesian Ministry of Health recommends SMART :

· Routine health checks ( mammography / breast ultrasound )

· E get rid of cigarette smoke

· Be diligent in activity physical (minimum 30 minutes / day )

· Nutritional diet balanced ( high) fiber , low fat)

· Rest Enough

· Manage stress

FAQ About Cancer Breast

Q: What are the symptoms? cancer breasts that need be aware of ?

A: Lump hard in the breast , changes skin ( such as skin oranges ), and butts enter to in .

Q: Can TNBC be cured ?

A: Yes, with combination chemotherapy and immunotherapy . Detection early become key main !

Q: How? method screening cancer breasts ?

A: SADARI ( examine) breast own ) monthly + mammography annual For age >40 years .

With understand subtype cancer breasts , patients and doctors Can choose the right therapy . Innovation like Mammaprint and its application DODGY increase hope life patient . For consultation more further , contact KALGen Hotline Innolab .

Source :

https://www.puskesmas-bantar.tasikmalayakota.go.id/info-kesehatan/detail/edisi-hari-kanker-sedunia-2024

https://www.mayoclinic.org/diseases-conditions/breast-cancer/symptoms-causes/syc-20352470

https://ayosehat.kemkes.go.id/topic-penyakit/neoplasma/kanker-payudara